Coeruloplasmin (Kupferstoffwechsel)
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Fragen und Antworten zu Coeruloplasmin
What is the respective laboratory value?
Coeruloplasmin is a copper transport protein that is mainly synthesized in the liver. The laboratory value measures the concentration of coeruloplasmin in the blood and is used to assess copper metabolism.
For whom is such a test to be considered?
A Coeruloplasmin test is recommended for: • People with suspected Wilson's disease (copper metabolism disorder) • Patients with symptoms such as tremor, stiffness or unclear liver disease • Patients with neurological symptoms and family history • Monitoring of patients with known copper metabolism problem
What is it used for?
The test serves the diagnosis and monitoring of Wilson's disease as well as the clarification of unclear liver diseases or neurological symptoms.
What can be inferred from that?
A low ceruloplasmin value often indicates Wilson's disease. Symptoms of this disease can include: • Neurological abnormalities such as tremors or movement disorders • Jaundice or enlarged liver • Kayser-Fleischer rings in the eyes (copper deposits) An elevated value is rare and usually associated with acute inflammation or pregnancy.
What is the ideal time for a test?
The testing can be carried out at any time of the day. For the clarification of Wilson's disease, additional tests such as the determination of the copper level in the urine are usually required.
Particularly interesting?
Ceruloplasmin values are often reduced in Wilson's disease, as copper is stored in the tissues instead of in the blood. • A normal value does not always exclude Wilson's disease; additional diagnostics such as a liver biopsy may be required. • Inflammations and pregnancy can increase ceruloplasmin without an underlying disease being present.