Homocystein

Homocysteine is an amino acid that is produced during the breakdown of methionine. The laboratory value measures the concentration of homocysteine in the blood plasma, which is a marker for methionine metabolism and cardiovascular risk.

The translation is: A homocysteine test is recommended for: • Persons with a family history of cardiovascular disease or stroke • Patients with unexplained thrombosis or vascular disease • Individuals suspected of vitamin B12 or folate deficiency • Women with recurrent miscarriages • Patients with neurological symptoms that could indicate a vitamin B deficiency

The test serves to assess cardiovascular risk, diagnose deficiencies in vitamin B6, B12 or folate, and clarify thrombosis risks. It is also used to evaluate methionine metabolism.

An elevated homocysteine level can be caused by vitamin B12, B6 or folate deficiency and is associated with an increased risk of: • Arteriosclerosis (vascular calcification) • Heart attack and stroke • Thrombosis Symptoms of an elevated homocysteine level are often non-specific, but may include neurological complaints. A low value is generally harmless and indicates normal methionine metabolism.

The testing is best done fasting, as food intake can affect the homocysteine level. Medications should also be paused beforehand if possible.

• An elevated homocysteine level is an independent risk factor for cardiovascular diseases. • Vegetarian or vegan diets can lead to elevated levels due to vitamin B12 deficiency. • A reduction in homocysteine levels through supplementation with B vitamins does not always significantly reduce cardiovascular risk and should be monitored closely.