IgA (Immunglobulin A)

IgA is an antibody that plays an important role in the immune system, especially in the mucous membranes of the gastrointestinal tract, the respiratory tract, and the urogenital tract. The laboratory value measures the concentration of IgA in the blood and is used to assess the immune status and chronic infections.

An IgA test is recommended for: • People with recurrent infections, especially of the mucous membranes • Patients with suspected autoimmune diseases such as celiac disease or IgA nephropathy • Diagnosis and monitoring of chronic infections • Patients with suspected immunodeficiencies or excessive antibody production

The test serves the diagnosis of immunodeficiencies, chronic infections and autoimmune diseases. It is also used to evaluate the function of the immune system.

An elevated IgA level indicates: • Chronic infections (e.g. respiratory diseases) • Autoimmune diseases such as celiac disease or IgA nephropathy • Liver diseases such as cirrhosis A low value indicates an IgA deficiency, which is associated with an increased risk of infections. Symptoms of abnormal IgA levels can include: • Frequent infections of the respiratory or gastrointestinal tract • Unexplained inflammation or autoimmune reactions

The testing can be carried out at any time of the day and is independent of food intake.

• An IgA deficiency is one of the most common immunodeficiencies and often remains asymptomatic, but can increase the risk of infections. • If celiac disease is suspected, in addition to IgA, a specific antibody test (tTGIgA) should be performed. • Chronically elevated IgA levels can indicate IgA nephropathy, a common cause of kidney damage.