Vitamin B12
The test determines the concentration of the active vitamin B12-holotranscobalamin in the blood. According to the National Consumption Study II, many people in Germany do not reach the recommended intake of vitamin B12. This can be caused by a vegan or vegetarian diet, but also by intestinal diseases or increased demand, for example in old age or during pregnancy. A deficiency of vitamin B12 can lead to a variety of symptoms that affect physical and mental health.
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Fragen und Antworten zu Vitamin B12
What is the respective laboratory value?
Vitamin B12 (Cobalamin) is a water-soluble vitamin that is essential for the formation of red blood cells, DNA synthesis, and the function of the nervous system. The laboratory value measures the concentration of vitamin B12 in the blood serum, which provides information about the supply status in the body.
For whom is such a test to be considered?
A Vitamin B12 test is recommended for: People with symptoms such as fatigue, concentration problems or neurological complaints (e.g. tingling in hands and feet) Vegetarians and vegans, as Vitamin B12 is mainly found in animal foods Older people, whose absorption of Vitamin B12 may be impaired by age-related changes in the stomach People with chronic gastrointestinal diseases (e.g. celiac disease, Crohn's disease, ulcerative colitis) Patients suspected of having pernicious anemia (an autoimmune disease that blocks B12 absorption)
What is it used for?
The test serves to diagnose a vitamin B12 deficiency, which can lead to anemia and neurological damage. It also helps to detect an oversupply due to excessive intake of dietary supplements.
What can be inferred from that?
A low value indicates a deficiency that can trigger the following symptoms: Fatigue and weakness Memory problems or cognitive impairments Tingling or numbness in hands and feet (neuropathies) Paleness or yellowish skin (indication of anemia) Mood swings or depression An elevated value can indicate liver disease or overdose from dietary supplements, but this is rare.
What is the ideal time for a test?
The testing is useful in case of symptoms of a deficiency or in risk groups (e.g. vegetarians or elderly people). The vitamin B12 status should also be checked before a planned pregnancy. The testing can be done at any time of the day and is independent of food intake.
Particularly interesting?
The serum B12 measurement alone is often not enough to reliably diagnose a deficiency. Supplementary tests such as the measurement of holo-transcobalamin (holo-TC) may be necessary. A deficiency is usually not caused by insufficient intake, but by absorption problems in the gastrointestinal tract. Alcohol abuse and certain medications (e.g. proton pump inhibitors) can inhibit the absorption of vitamin B12.