AST (Aspartat-Aminotransferase)

AST is an enzyme that occurs in various tissues, especially in the liver, in the heart muscle and in the muscles. The laboratory value measures the concentration of AST in the blood and is used to assess liver and heart function as well as muscle damage.

A AST test is recommended for: • Persons with suspected liver damage or liver diseases (e.g. hepatitis, cirrhosis of the liver) • Patients with symptoms such as jaundice, fatigue or pain in the upper abdomen • People with suspected heart attack or muscle damage • Monitoring of patients with known liver or heart problems

The test serves the diagnosis and monitoring of diseases that are associated with cell damage in the liver, heart or muscles. It is often measured together with ALT to distinguish between liver and heart problems.

Here is the translation: An elevated AST value can indicate the following conditions: • Liver damage due to hepatitis, alcohol abuse or medication • Heart attack • Muscle diseases such as myositis or muscular dystrophy A low value is unremarkable and has no clinical significance. Symptoms of elevated AST can include: • Jaundice or dark urine in liver problems • Chest pain or shortness of breath in heart problems • Muscle pain or weakness in muscle diseases

The testing can be carried out at any time of the day.

• AST is less specific for the liver than ALT, as it occurs in many tissues. • The ratio of AST to ALT (De-Ritis ratio) can help distinguish between alcoholic and non-alcoholic liver damage. • Muscle injuries or strenuous physical exertion can also increase AST.